| FC Midtjylland (DEN) v FC Lokomotiv Moskva (RUS) |
| FC Groningen (NED) v ACF Fiorentina (ITA) |
| FK Rabotnicki (MKD) v Bolton Wanderers FC (ENG) |
| Sevilla FC (ESP, holders) / AEK Athens FC (GRE) v FC Salzburg (AUT) |
| FC Nürnberg (GER) v AFC Rapid Bucuresti (ROU) |
| Everton FC (ENG) v FC Metalist Kharkiv (UKR) |
| FC Zenit St. Petersburg (RUS) v R. Standard de Liège (BEL) |
| Bayer 04 Leverkusen (GER) v UD Leiria (POR) |
| Villarreal CF (ESP) v FC BATE Borisov (BLR) |
| FC Sion (SUI) v Galatasaray SK (TUR) |
| Club Atlético de Madrid (ESP) v Kayseri Erciyesspor (TUR) |
| FC Girondins de Bordeaux (FRA) v Tampere United (FIN) |
| Panathinaikos FC (GRE) v FC Artmedia Petržalka (SVK) |
| AC Sparta Praha (CZE) v Odense BK (DEN) |
| FC Zürich (SUI) v Empoli FC (ITA) |
| FC Sochaux-Montbéliard (FRA) v Panionios GSS (GRE) |
| SK Rapid Wien (AUT) v RSC Anderlecht (BEL) |
| FC Paços de Ferreira (POR) v AZ Alkmaar (NED) |
| UC Sampdoria (ITA) v Aalborg BK (DEN) |
| FC Spartak Moskva (RUS) v BK Häcken (SWE) |
| Hammarby (SWE) v SC Braga (POR) |
| Larissa FC (GRE) v Blackburn Rovers FC (ENG) |
| FK Mladá Boleslav (CZE) v US Città di Palermo (ITA) |
| NK Dinamo Zagreb (CRO) v AFC Ajax (NED) |
| Stade Rennais FC (FRA) v PFC Lokomotiv Sofia (BUL) |
| SK Brann (NOR) v Club Brugge KV (BEL) |
| FC Bayern München (GER) v CF Os Belenenses (POR) |
| Aberdeen FC (SCO) v FC Dnipro Dnipropetrovsk (UKR) |
| SC Heerenveen (NED) v Helsingborgs IF (SWE) |
| Toulouse FC (FRA) v PFC CSKA Sofia (BUL) |
| Hamburger SV (GER) v PFC Litex Lovech (BUL) |
| FK Sarajevo (BIH) v FC Basel 1893 (SUI) |
| FK Austria Wien (AUT) v Vålerenga IF (NOR) |
| AIK Solna (SWE) v Hapoel Tel-Aviv FC (ISR) |
| Aris Thessaloniki FC (GRE) v Real Zaragoza (ESP) |
| FC Dinamo 1948 Bucuresti (ROU) v IF Elfsborg (SWE) |
| Tottenham Hotspur FC (ENG) v Anorthosis Famagusta FC (CYP) |
| RC Lens (FRA) v FC København (DEN) |
| Getafe CF (ESP) v FC Twente (NED) |
| Groclin Grodzisk Wielkopolski (POL) v FK Crvena Zvezda (SRB) |
